Medizinische Universität Graz

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Titel

Systemic Treatment of Advanced Basal Cel Carcinoma With Drugs That Target The Hedgehog Pathway

Kurzfassung

The availability of systemic therapies developed to treat both LaBCC and MBCC represents new milestones toward efforts to control this progressive disease. Although HHPIs are approved for these indications by both the FDA and EMA, drug use results in adverse events in nearly all patients, including some that require discontinuation of the treatment regimen. In some cases, dose reduction and/or dose interruption can be implemented to provide the patient with some time to recover and then continue treatment at a later date.
Unfortunately, patients can develop drug resistance as their tumors develop new gene mutations and alternate pathways that permit them to overcome the effects of a given HHPI. New targeted treatments designed to overcome primary drug resistance by blocking one or more alternative pathways leading to tumor proliferation are currently in development. It will be important to continue with these research efforts and to elucidate the mechanisms underlying these critical pathways so that they can be targeted effectively in clinical practice.

Schlagwörter

Advanced Basal Cell Carcinoma; Hedgehog Pathway

Anzahl Seiten

Publikationsjahr

2023

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